Salvia dumetorum essential oil: GC-MS analysis, antibacterial activity and effect on the formation of Streptococcus mutans biofilms.

Autor: Levaya YК; School of Pharmacy, NJSC 'Karaganda Medical University', Karaganda, Kazakhstan., Atazhanova GА; School of Pharmacy, NJSC 'Karaganda Medical University', Karaganda, Kazakhstan., Kacergius Т; Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Lithuania., Ivasenko SА; School of Pharmacy, NJSC 'Karaganda Medical University', Karaganda, Kazakhstan., Marchenko AB; School of Pharmacy, NJSC 'Karaganda Medical University', Karaganda, Kazakhstan., Ishmuratova MY; Department of Botany, NJSC 'E.A. Buketov Karaganda University', Karaganda, Kazakhstan., Smagulov МК; Department of Botany, NJSC 'E.A. Buketov Karaganda University', Karaganda, Kazakhstan.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Oct; Vol. 38 (20), pp. 3555-3561. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1080/14786419.2023.2256019
Abstrakt: Salvia dumetorum essential oil (SDEO) was obtained using a Clevenger apparatus by hydrodistillation approach. The chemical composition of the essential oil was determined by GC-MS analysis. In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus , Bacillus subtilis , Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium. During the study, no antibacterial activity was detected against E. coli and C. albicans . These results demonstrated that SDEO can be used in the development of new antibacterial and anti-caries therapeutic dental products.
Databáze: MEDLINE
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