The involvement of language-associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations.

Autor: Tahedl M; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland., Tan EL; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland., Chipika RH; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland., Lope J; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland., Hengeveld JC; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doherty MA; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., McLaughlin RL; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Hardiman O; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland., Hutchinson S; Department of Neurology, St James's Hospital, Dublin, Ireland., McKenna MC; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland., Bede P; Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Dublin, Ireland.; Department of Neurology, St James's Hospital, Dublin, Ireland.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2023 Nov; Vol. 13 (11), pp. e3250. Date of Electronic Publication: 2023 Sep 11.
DOI: 10.1002/brb3.3250
Abstrakt: Background: Language deficits are cardinal manifestations of some frontotemporal dementia (FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic lateral sclerosis (ALS). They have considerable social and quality-of-life implications, and adaptive strategies are challenging to implement. While the neuropsychological profiles of ALS-FTD phenotypes are well characterized, the neuronal underpinnings of language deficits are less well studied.
Methods: A multiparametric, quantitative neuroimaging study was conducted to characterize the involvement of language-associated networks, tracts, and cortical regions with a panel of structural, diffusivity, and functional magnetic resonance imaging (MRI) metrics. Seven study groups were evaluated along the ALS-FTD spectrum: healthy controls (HC), individuals with ALS without cognitive impairment (ALSnci), C9orf72-negative ALS-FTD, C9orf72-positive ALS-FTD, behavioral-variant FTD (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). The integrity of the Broca's area, Wernicke's area, frontal aslant tract (FAT), arcuate fascicle (AF), inferior occipitofrontal fascicle (IFO), inferior longitudinal fascicle (ILF), superior longitudinal fascicle (SLF), and uncinate fascicle (UF) was quantitatively evaluated. The functional connectivity (FC) between Broca's and Wernicke' areas and FC along the FAT was also specifically assessed.
Results: Patients with nfvPPA and svPPA exhibit distinctive patterns of gray and white matter degeneration in language-associated brain regions. Individuals with bvFTD exhibit Broca's area, right FAT, right IFO, and UF degeneration. The ALSnci group exhibits Broca's area atrophy and decreased FC along the FAT. Both ALS-FTD cohorts, irrespective of C9orf72 status, show bilateral FAT, AF, and IFO pathology. Interestingly, only C9orf72-negative ALS-FTD patients exhibit bilateral uncinate and right ILF involvement, while C9orf72-positive ALS-FTD patients do not.
Conclusions: Language-associated tracts and networks are not only affected in language-variant FTD phenotypes but also in ALS and bvFTD. Language domains should be routinely assessed in ALS irrespective of the genotype.
(© 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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