Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis.

Autor: Costa-Guda J; Center for Regenerative Medicine and Skeletal Development, University of Connecticut School of Dental Medicine, Farmington, CT 06030-3101, USA.; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Corrado K; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Bellizzi J; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Saria E; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Saucier K; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Guemes-Aragon M; Section of Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Kakar G; Section of Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Rose M; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Pascal M; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Alander C; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA., Mallya SM; Section of Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Arnold A; Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030-3101, USA.
Jazyk: angličtina
Zdroj: Endocrinology [Endocrinology] 2023 Sep 23; Vol. 164 (11).
DOI: 10.1210/endocr/bqad137
Abstrakt: Primary hyperparathyroidism (PHPT) is a common endocrinopathy for which several pathogenic mechanisms, including cyclin D1 overexpression, have been identified. Vitamin D nutritional status may influence parathyroid tumorigenesis, but evidence remains circumstantial. To assess the potential influence of vitamin D insufficiency/deficiency on initiation or progression of parathyroid tumorigenesis, we superimposed vitamin D insufficiency or deficiency on parathyroid tumor-prone parathyroid hormone-cyclin D1 transgenic mice. Mice were placed on diets containing either 2.75 IU/g, 0.25 IU/g, or 0.05 IU/g cholecalciferol, either prior to expected onset of PHPT or after onset of biochemical PHPT. When introduced early, superimposed vitamin D insufficiency/deficiency had no effect on serum calcium or on parathyroid gland growth. However, when introduced after the onset of biochemical PHPT, vitamin D deficiency led to larger parathyroid glands without differences in serum biochemical parameters. Our results suggest that low vitamin D status enhances proliferation of parathyroid cells whose growth is already being tumorigenically driven, in contrast to its apparent lack of direct proliferation-initiating action on normally growing parathyroid cells in this model. These results are consistent with the hypothesis that suboptimal vitamin D status may not increase incidence of de novo parathyroid tumorigenesis but may accelerate growth of a preexisting parathyroid tumor.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze: MEDLINE
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