The role of Bacillus Calmette-Guérin administration on the risk of dementia in bladder cancer patients: a systematic review and meta-analysis.

Autor:	Han C; Department of Outpatient, Shandong Mental Health Center, Jinan, China., Wang J; Department of Geriatrics, Shandong Mental Health Center, Jinan, China., Chen YL; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, China.; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China., Guan CP; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, China.; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China., Zhang YA; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China.; Department of Cardiovascular Surgery, Shandong Public Health Clinical Center, Shandong University, Jinan, China., Wang MS; Department of Lab Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, China.; Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2023 Aug 24; Vol. 15, pp. 1243588. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).
DOI:	10.3389/fnagi.2023.1243588
Abstrakt:	Background: Previous cohort studies have found an association between Bacillus Calmette-Guérin (BCG) administration and incident dementia. In the systematic review and meta-analysis, we aimed to summarize the current evidence of the effect of BCG use on the risk of developing dementia. Methods: We searched six databases until 20 May 2023 for studies investigating the risk of dementia and BCG administration. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were pooled in the meta-analysis. Meta-regression, subgroup, and sensitivity analysis were conducted as well. Results: Of the 4,043 records initially evaluated, five articles were included for final analysis, with a total of 45,407 bladder cancer (BC) patients. All five studies were evaluated and rated as with high quality, and a low possibility of publication bias was indicated. A significant association between BCG and the incidence of dementia in BC patients was found in all five studies. Although a high heterogeneity (I 2 = 84.5%, p < 0.001) was observed, the pooled HR was 0.55 (0.42-0.73), indicating that BCG exposure or treatment reduced the risk of incident dementia by 45%. Moreover, the sensitivity analysis showed good robustness of the overall effect with no serious publication bias. Conclusion: BCG administration is associated with a significantly lower risk of developing dementia. However, an epidemiological cohort is needed to establish a relationship between BCG use and incident dementia in the normal population. Once the relationship is confirmed, more people may benefit from the association. Systematic Review Registration: identifier: CRD42023428317. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Han, Wang, Chen, Guan, Zhang and Wang.)
Databáze:	MEDLINE
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