Probing the genomic landscape of human sexuality: a critical systematic review of the literature.

Autor:	Bragazzi NL; Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON, Canada.; Postgraduate School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; United Nations Educational, Scientific and Cultural Organization (UNESCO) Chair, Health Anthropology Biosphere and Healing Systems, University of Genoa, Genoa, Italy., Converti M; ASL Napoli 2 Nord, Naples, Italy., Crapanzano A; Department of Counseling, San Francisco State University, San Francisco, CA, United States., Zerbetto R; GESTALT Study Center (CSTG), Milano, Italy., Siri A; United Nations Educational, Scientific and Cultural Organization (UNESCO) Chair, Health Anthropology Biosphere and Healing Systems, University of Genoa, Genoa, Italy., Khamisy-Farah R; Clalit Health Services, Akko, Israel.; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2023 Aug 24; Vol. 14, pp. 1184758. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).
DOI:	10.3389/fgene.2023.1184758
Abstrakt:	Whether human sexuality is the result of nature or nurture (or their complex interplay) represents a hot, often ideologically driven, and highly polarized debate with political and social ramifications, and with varying, conflicting findings reported in the literature. A number of heritability and behavioral genetics studies, including pedigree-based investigations, have hypothesized inheritance patterns of human sexual behaviors. On the other hand, in most twin, adoption, and nuclear family studies, it was not possible to disentangle between underlying genetic and shared environmental sources. Furthermore, these studies were not able to estimate the precise extent of genetic loading and to shed light both on the number and nature of the putative inherited factors, which remained largely unknown. Molecular genetic studies offer an unprecedented opportunity to overcome these drawbacks, by dissecting the molecular basis of human sexuality and allowing a better understanding of its biological roots if any. However, there exists no systematic review of the molecular genetics of human sexuality. Therefore, we undertook this critical systematic review and appraisal of the literature, with the ambitious aims of filling in these gaps of knowledge, especially from the methodological standpoint, and providing guidance to future studies. Sixteen studies were finally retained and overviewed in the present systematic review study. Seven studies were linkage studies, four studies utilized the candidate gene approach, and five studies were GWAS investigations. Limitations of these studies and implications for further research are discussed. Competing Interests: Author MC was employed by ASL Napoli 2 Nord. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Bragazzi, Converti, Crapanzano, Zerbetto, Siri and Khamisy-Farah.)
Databáze:	MEDLINE
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