Neurotrophin-3 gene polymorphism in schizophrenia and its relation with diseases severity and cognitive dysfunction.
| Autor: | Keshri N; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Nandeesha H; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Rajappa M; Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Menon V; Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of neurosciences in rural practice [J Neurosci Rural Pract] 2023 Jul-Sep; Vol. 14 (3), pp. 501-508. Date of Electronic Publication: 2023 Jul 20. |
| DOI: | 10.25259/JNRP_34_2022 |
| Abstrakt: | Objectives: Synaptic plasticity markers are known to alter in schizophrenia. The objective of the study was to investigate the genotype and allele frequency of neurotrophin-3 (NT-3) gene polymorphism (rs6489630, rs6332, and rs11063714) and plasma NT-3 levels in schizophrenia and their relation with cognitive status. Materials and Methods: The study was conducted on 216 Schizophrenia patients and 216 controls. Single-nucleotide polymorphism (SNP) of NT-3 and its plasma levels were assessed in both groups. Cognitive status was evaluated using Addenbrooke Cognitive examination-III scores. Results: The rs6489630 polymorphism was found to be significantly associated with the severity of schizophrenia ( P = 0.004). The CT genotype ( P = 0.02, OR = 1.631 [1.10-2.43]) and minor allele T ( P = 0.004, OR = 1.58 [1.16-2.16]) of rs6489630 conferred an increased susceptibility to develop schizophrenia. The rs6332 variant was found to affect cognitive status significantly in schizophrenia ( P = 0.040), and memory dysfunction was seen in individuals with AG ( P < 0.01) and AA variant ( P = 0.03) of rs6332. Conclusion: We conclude that SNPs of NT-3 enhance the risk of schizophrenia and are related to cognitive dysfunction. Competing Interests: There are no conflicts of interest. (© 2023 Published by Scientific Scholar on behalf of Journal of Neurosciences in Rural Practice.) |
| Databáze: | MEDLINE |
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