PAPRIKA: A Question Bank for Assessing Psoriatic Arthritis Risk in Individuals of Diverse Ancestries.

Autor: Walsh JA; University of Utah School of Medicine, Salt Lake City.; Salt Lake City Veterans Affairs Health, Salt Lake City, USA., Carroll C; University of Utah School of Medicine, Salt Lake City., Callis Duffin K; University of Utah School of Medicine, Salt Lake City., Wang J; University of Utah School of Medicine, Salt Lake City., Krueger GG; University of Utah School of Medicine, Salt Lake City., Feng BJ; University of Utah School of Medicine, Salt Lake City.
Jazyk: angličtina
Zdroj: Arthritis care & research [Arthritis Care Res (Hoboken)] 2024 Mar; Vol. 76 (3), pp. 421-425. Date of Electronic Publication: 2024 Jan 20.
DOI: 10.1002/acr.25232
Abstrakt: Objective: We aimed to create a question bank about clinical factors for predicting the diagnoses of psoriatic arthritis in patients with psoriasis of various ancestries and skin tones, which can be completed entirely by patients.
Methods: Utah Psoriasis Initiative participants without a psoriatic arthritis diagnosis at enrollment were observed for diagnosis during the study period. We inferred ancestry from exome sequencing data and performed Cox proportional hazards regression to identify clinical predictors of psoriatic arthritis in different ancestry groups. Based on results and literature review, we developed a question bank for assessing psoriatic arthritis risk among patients with psoriasis in various ancestries.
Results: Patient-reported untreated psoriasis induration and history of fingernail psoriasis were associated with psoriatic arthritis in participants of European and non-European ancestry. We developed the Psoriatic Arthritis Prediction and Identification Question Bank for Diverse Ancestries (PAPRIKA) version 1.0, which included questions regarding psoriasis characteristics, arthritis symptoms, comorbidities, family history, and demographics. PAPRIKA is accessible at http://bjfenglab.org/.
Conclusion: The clinical features (untreated psoriasis induration and history of fingernail psoriasis) that can predict psoriatic arthritis in European individuals also work for non-European individuals. PAPRIKA can be used to gather psoriatic arthritis predictive data from patients with psoriasis without provider assistance and is relevant for patients across ancestries.
(© 2023 American College of Rheumatology.)
Databáze: MEDLINE
Externí odkaz: