Grey matter volume and CSF biomarkers predict neuropsychological subtypes of MCI.

Autor: Lefort-Besnard J; Normandie Univ, UNICAEN, INSERM, COMETE, Caen, France., Naveau M; Normandie Univ, UNICAEN, CNRS, CEA, INSERM, GIP Cyceron, Caen, France., Delcroix N; Normandie Univ, UNICAEN, CNRS, CEA, INSERM, GIP Cyceron, Caen, France., Decker LM; Normandie Univ, UNICAEN, INSERM, COMETE, Caen, France; Normandie Univ, UNICAEN, CIREVE, Caen, France. Electronic address: leslie.decker@unicaen.fr., Cignetti F; Univ. Grenoble Alpes, CNRS, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France. Electronic address: fabien.cignetti@univ-grenoble-alpes.fr.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Nov; Vol. 131, pp. 196-208. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1016/j.neurobiolaging.2023.07.006
Abstrakt: There is increasing evidence of different subtypes of individuals with mild cognitive impairment (MCI). An important line of research is whether neuropsychologically-defined subtypes have distinct patterns of neurodegeneration and cerebrospinal fluid (CSF) biomarker composition. In our study, we demonstrated that MCI participants of the ADNI database (N = 640) can be discriminated into 3 coherent neuropsychological subgroups. Our clustering approach revealed amnestic MCI, mixed MCI, and cluster-derived normal subgroups. Furthermore, classification modeling revealed that specific predictive features can be used to differentiate amnestic and mixed MCI from cognitively normal (CN) controls: CSF Aβ 1 42 concentration for the former and CSF Aβ 1-42 concentration, tau concentration as well as grey matter atrophy (especially in the temporal and occipital lobes) for the latter. In contrast, participants from the cluster-derived normal subgroup exhibited an identical profile to CN controls in terms of cognitive performance, brain structure, and CSF biomarker levels. Our comprehensive data analytics strategy provides further evidence that multimodal neuropsychological subtyping is both clinically and neurobiologically meaningful.
Competing Interests: Disclosure statement The authors have no actual or potential conflicts of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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