High-Sucrose Diet Accelerates Arthritis Progression in a Collagen-Induced Rheumatoid Arthritis Model.

Autor: Min Y; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Heo Y; Department of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Feng F; Department of Food Science and Nutrition, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Kim D; Division of Animal Genetics and Bioinformatics, The National Institute of Animal Science, RDA, Wanju, 55465, Republic of Korea., Kim M; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Yang J; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Kim HJ; Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Jee Y; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea.; Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Ghosh M; Department of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea.; Department of Biotechnology, School of Bio, Chemical and Processing Engineering (SBCE), Kalasalingam Academy of Research and Educational, Krishnankoil, 626126, India., Kang I; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea.; Department of Food Science and Nutrition, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea., Son YO; Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea.; Department of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju Special Self-Governing Province, Jeju, 63243, Republic of Korea.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2023 Oct; Vol. 67 (20), pp. e2300244. Date of Electronic Publication: 2023 Sep 08.
DOI: 10.1002/mnfr.202300244
Abstrakt: Scope: High dietary sugar and sweeteners are suspected to cause the development of rheumatoid arthritis (RA) symptoms through the induction of proinflammatory cytokine release. However, the mechanisms by which increased dietary sugar affects RA etiology are not yet fully understood. The study uses a mouse model of collagen-induced RA (CIA) to investigate the relationship between excessive sugar consumption and RA risk.
Methods and Results: RA-associated pathological features are assessed in the nonimmunized (NI) control group, the CIA-positive control group, and the CIA + high-sucrose diet (CIA+HS, 63% calories from sucrose) group. Compared with the CIA group, the CIA+HS group shows a greater increase in paw thickness and clinical scores, as well as, a higher degree of pannus formation and inflammation in the knee, ankle, and sole tissues. Moreover, the infiltration of immune cells is increased in the CIA+HS group. Although the expression of hepatic lipogenic genes, is not altered, that of toll-like receptor (TLR4) and IL-1β is considerably elevated in the CIA+HS group.
Conclusions: These findings suggest that excessive sucrose consumption causes hepatic fibrosis and inflammation, contributing to the pathophysiology of RA.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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