Association of Fibrinolytic Potential and Risk of Mortality in Cancer Patients.

Autor: Gois GSS; School of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil., Montalvão SAL; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Anhaia TRA; School of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil., Almeida MEA; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Martinelli BM; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Fernandes MCGL; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Hubers SC; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Ferreira MRM; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Ribeiro DD; Clinical Hospital of UFMG, Belo Horizonte 30130-100, MG, Brazil., Teixeira JC; Department of Obstetrics and Gynecology, Division of Oncology, Women's Hospital, CAISM-UNICAMP, University of Campinas, Campinas 13083-881, SP, Brazil., Carvalheira JBC; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Lima CSP; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Andreollo NA; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Etchebehere M; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Zambon L; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Ferreira U; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Tincani AJ; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Martins AS; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Coy CSR; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Seabra JCT; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Mussi RK; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Tedeschi H; Clinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil., Anninchino-Bizzacchi JM; School of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil.; Laboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil., Adventh Cancer Group
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Sep 03; Vol. 15 (17). Date of Electronic Publication: 2023 Sep 03.
DOI: 10.3390/cancers15174408
Abstrakt: Cancer is a leading cause of death, and the fibrinolytic system shows cooperative effects that facilitate the growth of tumors and the appearance of metastases. This prospective study aimed to evaluate the fibrinolytic potential in cancer patients and its association with mortality outcomes using the fluorometric method of simultaneous thrombin and plasmin generation. The study included 323 cancer patients and 148 healthy individuals. During the 12-month follow-up, 68 patients died. Compared to the control group, cancer patients showed alterations in thrombin production consistent with a hypercoagulability profile, and an increase in plasmin generation. Mortality risk was associated with two parameters of thrombin in both univariate and multivariable analysis: maximum amplitude (Wald 11.78, p < 0.001) and area under the curve (Wald 8.0, p < 0.005), while such associations were not observed for plasmin. In conclusion, this was the first study able to demonstrate the simultaneous evaluation of thrombin and plasmin generation in newly diagnosed untreated cancer patients. Patients with cancer have been observed to exhibit a hypercoagulable profile. During the study, two parameters linked to thrombin generation, MA and AUC, were identified and found to have a potential association with mortality risk. However, no associations were found with parameters related to plasmin generation.
Databáze: MEDLINE
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