| Autor: |
Andújar-Vera F; Bioinformatic Unit, Biosanitary Research Institute ibs.GRANADA, 18012 Granada, Spain., Alés-Palmer ML; Department of Pediatrics, University of Granada, 18016 Granada, Spain.; Department of Pediatrics, 'Virgen de las Nieves' University Hospital, 18014 Granada, Spain., Muñoz-de-Rueda P; Research Support Unit, Biosanitary Research Institute ibs.GRANADA, 18012 Granada, Spain., Iglesias-Baena I; Research Unit, GenActive Clinic & Research, 18193 Granada, Spain., Ocete-Hita E; Department of Pediatrics, University of Granada, 18016 Granada, Spain.; Department of Pediatrics, 'Virgen de las Nieves' University Hospital, 18014 Granada, Spain.; Biosanitary Research Institute ibs.GRANADA, 18012 Granada, Spain. |
| Abstrakt: |
Hepatotoxicity, a common adverse drug effect, has been extensively studied in adult patients. However, it is equally important to investigate this condition in pediatric patients to develop personalized treatment strategies for children. This study aimed to identify plasma biomarkers that characterize hepatotoxicity in pediatric patients through an observational case-control study. Metabolomic analysis was conducted on 55 pediatric patients with xenobiotic liver toxicity and 88 healthy controls. The results revealed clear differences between the two groups. Several metabolites, including hydroxydecanoylcarnitine, octanoylcarnitine, lysophosphatidylcholine, glycocholic acid, and taurocholic acid, were identified as potential biomarkers (area under the curve: 0.817; 95% confidence interval: 0.696-0.913). Pathway analysis indicated involvement of primary bile acid biosynthesis and the metabolism of taurine and hypotaurine ( p < 0.05). The findings from untargeted metabolomic analysis demonstrated an increase in bile acids in children with hepatotoxicity. The accumulation of cytotoxic bile acids should be further investigated to elucidate the role of these metabolites in drug-induced liver injury. |
