| Autor: |
Ho HY; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Lin CC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Lo YS; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Chuang YC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan., Abomughaid MM; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha 61922, Saudi Arabia., Hsieh MJ; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.; Doctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan. |
| Abstrakt: |
Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to investigate the anticancer effects of picrasidine J, a dimeric β-carboline-type alkaloid isolated from the southern Asian plant Picrasma quassioides. The results showed that picrasidine J significantly inhibits HNSCC cell motility, migration, and invasion. Specifically, picrasidine J inhibited the EMT process by upregulating E-cadherin and ZO-1 and downregulating beta-catenin and Snail. Moreover, picrasidine J reduced the expression of the serine protease KLK-10. At the signaling level, the compound reduced the phosphorylation of ERK. All these factors collectively facilitated the inhibition of HNSCC metastasis with picrasidine J. Taken together, the study identifies picrasidine J as a potential anticancer compound of plant origin that might be used clinically to prevent the distant metastasis and progression of HNSCC. |
