| Autor: |
Kruglova MP; I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8, 119991 Moscow, Russia., Ivanov AV; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia., Fedoseev AN; City Clinical Hospital No. 24 of Moscow Healthcare Department, Piscovaya St., 10, 127015 Moscow, Russia., Virus ED; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia., Stupin VA; Pirogov Russian National Research Medical University, Ostrovityanova St., 1, 117997 Moscow, Russia., Parfenov VA; I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8, 119991 Moscow, Russia., Titova SA; I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8, 119991 Moscow, Russia., Lazareva PI; I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8, 119991 Moscow, Russia., Kubatiev AA; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia., Silina EV; I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya St., 8, 119991 Moscow, Russia. |
| Abstrakt: |
We examined standard clinical and laboratory biochemical parameters, as well as the levels of aminothiols in the blood and urine (homocysteine (Hcy), cysteine (Cys), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)) via capillary electrophoresis in patients with CKD at stages II-V. Patient outcomes were assessed after five years. To complete forecasting, correlation and ROC analysis were performed. It was found that the levels of Cys and Hcy in blood plasma were earlier markers of CKD starting from stage II, while the levels of SAM and SAM/SAH in urine made it possible to differentiate between CKD at stages II and III. Blood plasma Hcy and urinary SAM and SAM/SAH correlated with mortality, but plasma Hcy concentrations were more significant. Thus, plasma Hcy, urine SAM, and SAM/SAH can be considered to be potential diagnostic and prognostic markers in patients with CKD. |
