Allele surfing causes maladaptation in a Pacific salmon of conservation concern.

Autor: Rougemont Q; Centre d'Ecologie Fonctionnelle et Evolutive, Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France., Leroy T; GenPhySE, INRAE, INP, ENVT, Université de Toulouse, Auzeville- Tolosane, France., Rondeau EB; Department of Fisheries and Ocean, Pacific Biological Station, Nanaimo, Canada., Koop B; Department of Biology, University of Victoria, Victoria, Canada., Bernatchez L; Département de Biologie, Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, Canada.
Jazyk: angličtina
Zdroj: PLoS genetics [PLoS Genet] 2023 Sep 08; Vol. 19 (9), pp. e1010918. Date of Electronic Publication: 2023 Sep 08 (Print Publication: 2023).
DOI: 10.1371/journal.pgen.1010918
Abstrakt: How various factors, including demography, recombination or genome duplication, may impact the efficacy of natural selection and the burden of deleterious mutations, is a central question in evolutionary biology and genetics. In this study, we show that key evolutionary processes, including variations in i) effective population size (Ne) ii) recombination rates and iii) chromosome inheritance, have influenced the genetic load and efficacy of selection in Coho salmon (Oncorhynchus kisutch), a widely distributed salmonid species on the west coast of North America. Using whole genome resequencing data from 14 populations at different migratory distances from their southern glacial refugium, we found evidence supporting gene surfing, wherein reduced Ne at the postglacial recolonization front, leads to a decrease in the efficacy of selection and a surf of deleterious alleles in the northernmost populations. Furthermore, our results indicate that recombination rates play a prime role in shaping the load along the genome. Additionally, we identified variation in polyploidy as a contributing factor to within-genome variation of the load. Overall, our results align remarkably well with expectations under the nearly neutral theory of molecular evolution. We discuss the fundamental and applied implications of these findings for evolutionary and conservation genomics.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Rougemont et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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