Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome.

Autor:	Gawra J; IHPE, Université de Perpignan Via Domitia, CNRS, Ifremer, Université de Montpellier, Perpignan, France., Valdivieso A; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Roux F; LIPME, INRAE, CNRS, Université de Toulouse, Castanet-Tolosan, France., Laporte M; Division de l'expertise sur la faune Aquatique, Ministère des Forêts, de la Faune et des Parcs (MFFP), 880 chemin Sainte-Foy, G1S 4X4 Québec, Québec, Canada., de Lorgeril J; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France.; Ifremer, IRD, Université de la Nouvelle-Calédonie, Université de La Réunion, ENTROPIE, Nouméa, Nouvelle-Calédonie, France., Gueguen Y; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France.; MARBEC, Université de Montpellier, CNRS, Ifremer, IRD, Sète, France., Saccas M; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Escoubas JM; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Montagnani C; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Destoumieux-Garzόn D; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Lagarde F; MARBEC, Université de Montpellier, CNRS, Ifremer, IRD, Sète, France., Leroy MA; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Haffner P; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France., Petton B; Université de Brest, Ifremer, CNRS, IRD, LEMAR, F-29280 Plouzané, France., Cosseau C; IHPE, Université de Perpignan Via Domitia, CNRS, Ifremer, Université de Montpellier, Perpignan, France., Morga B; Ifremer, ASIM, Adaptation Santé des Invertébrés Marins, La Tremblade, France., Dégremont L; Ifremer, ASIM, Adaptation Santé des Invertébrés Marins, La Tremblade, France., Mitta G; IHPE, Université de Perpignan Via Domitia, CNRS, Ifremer, Université de Montpellier, Perpignan, France.; Université de la Polynésie Française, ILM, IRD, Ifremer, F-98719 Tahiti, French Polynesia, France., Grunau C; IHPE, Université de Perpignan Via Domitia, CNRS, Ifremer, Université de Montpellier, Perpignan, France., Vidal-Dupiol J; IHPE, Université de Montpellier, CNRS, Ifremer, Université de Perpignan Via Domitia, Montpellier, France.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2023 Sep 08; Vol. 9 (36), pp. eadh8990. Date of Electronic Publication: 2023 Sep 08.
DOI:	10.1126/sciadv.adh8990
Abstrakt:	Disease emergence is accelerating with global changes. Understanding by which mechanisms host populations can rapidly adapt will be crucial for management practices. Pacific oyster mortality syndrome (POMS) imposes a substantial and recurrent selective pressure on oyster populations, and rapid adaptation may arise through genetics and epigenetics. In this study, we used (epi)genome-wide association mapping to show that oysters differentially exposed to POMS displayed genetic and epigenetic signatures of selection. Consistent with higher resistance to POMS, the genes targeted included many genes in several pathways related to immunity. By combining correlation, DNA methylation quantitative trait loci, and variance partitioning, we revealed that a third of phenotypic variation was explained by interactions between the genetic and epigenetic information, ~14% by the genome, and up to 25% by the epigenome alone. Similar to genetically based adaptation, epigenetic mechanisms notably governing immune responses can contribute substantially to the rapid adaptation of hosts to emerging infectious diseases.
Databáze:	MEDLINE
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