Nephrotic syndrome with Minimal Change Disease and Atopy in NorthAfrican adults.

Autor:	Hadhri A; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Mrabet S; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Ben Aicha N; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Fradi A; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Azzabi A; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Sahtout W; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Boukadida R; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Guedri Y; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Zellama D; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia., Abdessaied N; Department of Pathology - Farhat Hached University Hospital, Sousse, Tunisia., Ben Saad H; Laboratory of Physiology and Functional Explorations - Farhat Hached Hospital, Sousse, Tunisia., Achour A; Department of Nephrology, Dialysis, and Transplantation - Sahloul University Hospital, Sousse, Tunisia.
Jazyk:	angličtina
Zdroj:	La Tunisie medicale [Tunis Med] 2023 Feb 11; Vol. 101 (2), pp. 253-258. Date of Electronic Publication: 2023 Feb 11.
Abstrakt:	Introduction: In adults, minimal change disease (MCD) accounts for 15 to 25% of nephrotic syndrome (NS). Numerous reports have suggested a link between NS and atopy. However, data on treatment and prognosis of NS associated with allergy are limited. Aim: To examine the presenting characteristics, treatments and outcomes of adults with allergic MCD in a North African center. Methods: This was an observational study using retrospectively collected data. Patients were recruited from the Nephrology department of Sahloul Hospital (Sousse, Tunisia) from January 2006 to December 2020. Adults with a biopsy proved MCD, which was associated with atopy, were included. Results: Fifteen patients (eight males, age mean±SD: 34±13 years) were included. High eosinophil and immunoglobulin E (IgE) levels were noted in three and twelve patients respectively. The IgE mean level at the initial presentation was 1431 IU/ml. Allergic skin tests were positive in nine patients. All patients were treated with corticosteroids, five had anti-histamine therapy and five had hyposensitization therapy, which was successful in two patients. Thirteen patients had relapsed during follow-up. Mean eosinophil level was significantly higher in patients with frequent relapses compared to those with infrequent relapses (5415/mm³ vs. 239.12/mm³, respectively, p=0.022). Two patients had progressed to chronic renal failure. Conclusion: It is important to search for atopic disorders in patients with MCD to better control this disease and use specific treatments. However, the efficacy of anti-allergic therapies has to be proven.
Databáze:	MEDLINE
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