Decrease of left ventricular function measured by speckle-tracking echocardiography based on systemic lupus erythematosus severity in children.

Autor:	Rustam MI; Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia., Ghrahani R; Division of Allergy-Immunology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia., Hakim DDL; Division of Emergency and Intensive Care, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia., Kuswiyanto RB; Division of Cardiology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia., Dewi MM; Division of Neurology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia., Rahayuningsih SE; Division of Cardiology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia.
Jazyk:	angličtina
Zdroj:	Cardiology in the young [Cardiol Young] 2024 Mar; Vol. 34 (3), pp. 624-627. Date of Electronic Publication: 2023 Sep 08.
DOI:	10.1017/S1047951123003232
Abstrakt:	Introduction: Systemic lupus erythematosus in children generally manifests more severely with a more aggressive disease course. Cardiac involvement in systemic lupus erythematosus often does not show specific signs and symptoms, but speckle-tracking echocardiography can detect cardiac dysfunction. This study aimed to determine the differences in left ventricular function as measured by speckle-tracking echocardiography in children with various severity of systemic lupus erythematosus activity. Methods: A cross-sectional study of 49 children diagnosed with systemic lupus erythematosus are currently undergoing outpatient or inpatient care at Dr Hasan Sadikin General Hospital, Bandung, from May 2023 to June 2023. Disease activity was assessed by Mexican Version of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) with a score of 2-5 classified as mild activity, 6-9 as moderate, and ≥10 as severe. Each subject underwent conventional echocardiography and speckle-tracking echocardiography with a Philips EPIQ machine performed by a Pediatric Cardiologist Consultant 10 days after inclusion. Results: Fifteen (30.6%) subjects had mild disease activity, and 34 (69.4%) subjects had moderate disease activity. Most subjects (81.96%) were female with an average age of 15 years. The mean ejection fraction and fractional shortening as well as the median E/A ratio in the mild and moderate disease activity groups were not significantly different (65.76 versus 67.38%, 35.73 versus 37.11%, 1.6 versus 1.5%, respectively, p > 0.005). The global longitudinal strain in the moderate activity group was reduced more significantly than in the mild activity group (-16.58 versus -19.65, p = 0.008). Conclusion: Left ventricular function as measured by speckle-tracking echocardiography was lower in children with moderate systemic lupus erythematosus activity than those with mild disease activity.
Databáze:	MEDLINE
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