Congenital cleft lip and palate and elevated risks of major psychiatric disorders: A nationwide longitudinal study.

Autor:	Huang HH; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Cell and Developmental Biology, Medical School, University of Michigan, Michigan, USA., Hsu JW; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Huang KL; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Su TP; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan., Chen TJ; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu, Taiwan., Tsai SJ; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen MH; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Clinical child psychology and psychiatry [Clin Child Psychol Psychiatry] 2024 Apr; Vol. 29 (2), pp. 637-647. Date of Electronic Publication: 2023 Sep 08.
DOI:	10.1177/13591045231200665
Abstrakt:	Background: Congenital cleft lip and palate (CCLP) may be associated with major psychiatric disorders, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, bipolar disorder, and major depressive disorder. Methods: From the Taiwan National Health Insurance Research Database, 1,158 children and adolescents with CCLP and 11,580 age/sex-matched controls without CCLP were included in this study between 2001 and 2010; they were followed up until the end of 2011 to identify the aforementioned major psychiatric disorders. Results: After adjustment for age, sex, income, residence, and family history, the Cox regression model revealed a positive relationship of CCLP with subsequent schizophrenia (hazard ratio [HR]: 7.60, 95% confidence interval [CI]: 2.03-28.54), ASD (HR: 6.03, 95% CI: 1.76-20.61), and ADHD (HR: 7.33, 95% CI: 5.01-10.73). Discussion: These findings suggest that clinicians should be attentive to the presence or emergence of mental health conditions in patients with CCLP. Further studies are necessary to investigate the pathogenesis between CCLP and major psychiatric disorders. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu