Risk and diagnostic factors and therapy outcome of neonatal early onset sepsis in ICU patients of Saudi Arabia: a systematic review and meta analysis.

Autor:	Alshammari MK; Department of Clinical Pharmacy, King Fahad Medical City Hospital, Riyadh, Saudi Arabia., Alsanad AH; Department of Neonatal Intensive Care Unit, Maternity and Children Hospital, Dammam, Saudi Arabia., Alnusayri RJ; Department of Pharmacy, Maternity and Children Hospital, Ministry of Health, Jouf, Saudi Arabia., Alanazi AS; Department of Medicine, Ministry of Health, Abha, Saudi Arabia., Shamakhi FQ; Department of Medicine, Ministry of Health, Abha, Saudi Arabia., Alshahrani KM; Department of Medicine, Ministry of Health, Abha, Saudi Arabia., Alshahrani AM; Department of Medicine, Ministry of Health, Khamis Mushait, Saudi Arabia., Yahya G; Department of Medicine, Ministry of Health, Abha, Saudi Arabia., Alshahrani AA; Department of Medicine, King Khaled University, Abha, Saudi Arabia., Alshahrani TS; College of Medicine, King Khalid University, Al Fara, Saudi Arabia., Sultan HS; College of Medicine, King Khalid University, Al Fara, Saudi Arabia., Alshahrani FM; Department of Pharmacy, Dr. Sulaiman Al-Habib Hospital, Khobar, Saudi Arabia., Alreshidi FA; Department of Nursing Office, Hail General Hospital, Hail, Saudi Arabia., Alnigaidan RA; Department of Pharmacy, Al-Dawaa Medical Services Company Limited, Unaizah, Saudi Arabia., Almazyad AA; Department of Pharmacy, Qassim University Medical City Hospital, Buraidah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2023 Aug 23; Vol. 11, pp. 1206389. Date of Electronic Publication: 2023 Aug 23 (Print Publication: 2023).
DOI:	10.3389/fped.2023.1206389
Abstrakt:	Background: Neonatal early onset sepsis (NEOS) is a serious and potentially life-threatening condition affecting newborns within the first few days of life. While the diagnosis of NEOS was based on clinical signs and symptoms in the past, recent years have seen growing interest in identifying specific diagnostic factors and optimizing therapy outcomes. This study aims to investigate the diagnostic and risk factors and therapy outcomes of neonatal EOS in ICU patients in Saudi Arabia, with the goal of improving the management of neonatal EOS in the country. Methods: This method outlines the protocol development, search strategy, study selection, and data collection process for a systematic review on neonatal early onset sepsis in Saudi Arabian ICU patients, following the PRISMA 2020 guidelines. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is a well-established guideline that provides a framework for conducting systematic reviews and meta-analyses in a transparent and standardized manner. It aims to improve the quality and reporting of such research by ensuring clear and comprehensive reporting of study methods, results, and interpretations. The search strategy included electronic databases (PubMed, Embase, Google Scholar, Science Direct, and the Cochrane Library) and manual search of relevant studies, and data were extracted using a standardized form. Results: The systematic review included 21 studies on neonatal sepsis in Saudi Arabia, with varying study designs, sample sizes, and prevalence rates of sepsis. Group B streptococcus and E. coli were the most commonly isolated pathogens. Various diagnostic factors and risk factors were reported, including hematological parameters, biomarkers, and blood cultures. The quality of the included studies was assessed using the Newcastle-Ottawa Scale and Joanna Briggs Institute critical checklist. Conclusions: The review identified a number of risk and diagnostic factors and therapy outcomes for neonatal sepsis. However, most of the studies were having small scale cohort groups. Further research with controlled study designs is needed to develop effective prevention and management strategies for neonatal sepsis in Saudi Arabia. Competing Interests: RA was employed by Al-Dawaa Medical Services Company Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Alshammari, Alsanad, Alnusayri, Alanazi, Shamakhi, Alshahrani, Alshahrani, Yahya, Alshahrani, Alshahrani, Sultan, Alshahrani, Alreshidi, Alnigaidan and Almazyad.)
Databáze:	MEDLINE
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