3D-printed wound dressings containing a fosmidomycin-derivative prevent Acinetobacter baumannii biofilm formation.

Autor:	van Charante F; Laboratory of Pharmaceutical Microbiology, Ghent University, 9000 Ghent, Belgium., Martínez-Pérez D; Biomaterials, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland., Guarch-Pérez C; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Courtens C; Laboratory of Medicinal Chemistry, Ghent University, 9000 Ghent, Belgium., Sass A; Laboratory of Pharmaceutical Microbiology, Ghent University, 9000 Ghent, Belgium., Choińska E; Biomaterials, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland., Idaszek J; Biomaterials, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland., Van Calenbergh S; Laboratory of Medicinal Chemistry, Ghent University, 9000 Ghent, Belgium., Riool M; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Zaat SAJ; Department of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Święszkowski W; Biomaterials, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland., Coenye T; Laboratory of Pharmaceutical Microbiology, Ghent University, 9000 Ghent, Belgium.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2023 Aug 07; Vol. 26 (9), pp. 107557. Date of Electronic Publication: 2023 Aug 07 (Print Publication: 2023).
DOI:	10.1016/j.isci.2023.107557
Abstrakt:	Acinetobacter baumannii causes a wide range of infections, including wound infections. Multidrug-resistant A. baumannii is a major healthcare concern and the development of novel treatments against these infections is needed. Fosmidomycin is a repurposed antimalarial drug targeting the non-mevalonate pathway, and several derivatives show activity toward A. baumannii . We evaluated the antimicrobial activity of CC366, a fosmidomycin prodrug, against a collection of A. baumannii strains, using various in vitro and in vivo models; emphasis was placed on the evaluation of its anti-biofilm activity. We also developed a 3D-printed wound dressing containing CC366, using melt electrowriting technology. Minimal inhibitory concentrations of CC366 ranged from 1 to 64 μg/mL, and CC366 showed good biofilm inhibitory and moderate biofilm eradicating activity in vitro . CC366 successfully eluted from a 3D-printed dressing, the dressings prevented the formation of A. baumannnii wound biofilms in vitro and reduced A. baumannii infection in an in vivo mouse model. Competing Interests: The authors declare no competing interests. (© 2023 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu