Role of Vitamin D in Management of Diabetes and Unresolved Cardiovascular Diseases.

Autor: Upadhyay PK; Institute of Pharmaceutical Research, GLA University, Mathura 281406, Uttar Pradesh, India., Thakur N; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India., Vishwakarma VK; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India., Srivastav RK; Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur 228119, India., Ansari TM; Department of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.
Jazyk: angličtina
Zdroj: Current diabetes reviews [Curr Diabetes Rev] 2024; Vol. 20 (6), pp. e010923220647.
DOI: 10.2174/1573399820666230901151019
Abstrakt: Background: Vitamin D deficiency is becoming a widely recognized global health issue. Serum values of 25-(OH) vitamin D (<20 ng/ml) are used to identify vitamin D deficiency. By prompting vascular endothelial cells to activate their nuclear receptor in cardio-myocytes, Vitamin D regulates obesity, Renin-angiotensin system (RAS), energy consumption, and pancreatic cell function. Vitamin D deficiency has been associated with diabetes, asthma, hyperlipidaemia, and pulmonary hypertension in humans.
Methods: PubMed and Google Scholar databases were utilised to search the literature on vitamin D and related diseases.
Result: It is also linked to an elevated risk of death and heart disease. On the other hand, metaanalyses of vitamin D intervention and trials have found no substantial changes in insulin sensitivity, lipid markers, or blood pressure, which result in the association between deficiency of vitamin D and cardiovascular disease.
Conclusion: In this review, we present the most recent research on the effects of Vitamin D therapy on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.
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Databáze: MEDLINE
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