Recent developments in the diagnosis, treatment, and management of Papillon-Lefèvre Syndrome.

Autor: Haghgoo R; Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran., Mehran M; Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran., Banakar M; Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran. Dr.mbanakar@gmail.com.; Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Dr.mbanakar@gmail.com.
Jazyk: angličtina
Zdroj: Evidence-based dentistry [Evid Based Dent] 2024 Mar; Vol. 25 (1), pp. 3-5. Date of Electronic Publication: 2023 Sep 07.
DOI: 10.1038/s41432-023-00932-1
Abstrakt: Data Sources: A systematic search of PubMed, LIVIVO, and Ovid was conducted up to March 2021. These databases were searched for relevant clinical studies on periodontal treatment success in individuals with Papillon-Lefèvre syndrome (PLS).
Study Selection: Clinical studies reporting successful treatment outcomes defined as the loss of four or fewer permanent teeth due to periodontitis and the arrest of periodontitis or probing depths of 5 mm or less in individuals with PLS followed up for ≥24 months were included, and data extracted.
Data Extraction and Synthesis: Twelve studies reporting on nine PLS patients met the inclusion criteria. The extracted main outcomes in the studies reporting successful periodontal treatment in PLS were as follows: (1) clinical and genetic diagnosis of PLS; (2) age at baseline; (3) initial dental, periodontal parameters, and microbiological assessment, if available; (4) description of disease progression and applied therapies; and (5) outcome and follow-up.
Results: Twelve studies reporting nine individuals were included. The timely extraction of affected or all primary teeth, compliance with oral hygiene instructions, supra- and subgingival debridement within frequent supportive periodontal care intervals, and adjunctive systemic antibiotic therapy in most patients affected a halt in disease progression. Suppression of Aggregatibacter actinomycetemcomitans below detection limits was associated with periodontal stabilization.
Conclusions: An intensive, multidisciplinary approach with strict compliance may enable the decelerated progression of PLS-associated periodontitis. The early diagnosis of PLS and the suppression of A. actinomycetemcomitans below the detection level might be critical factors for treatment success. It required significant effort and patient compliance. The study emphasized the importance of timely interventions, oral hygiene maintenance, regular professional dental care, and, in some cases, systemic antibiotics.
(© 2023. The Author(s), under exclusive licence to British Dental Association.)
Databáze: MEDLINE
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