Q fever immunology: the quest for a safe and effective vaccine.

Autor: Sam G; Centre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, 4111, Australia., Stenos J; Australian Rickettsial Reference Laboratory, University Hospital, Geelong, VIC, 3220, Australia., Graves SR; Australian Rickettsial Reference Laboratory, University Hospital, Geelong, VIC, 3220, Australia.; Elizabeth Macarthur Agricultural Institute, NSW Department of Primary Industries, Menangle, NSW, 2567, Australia., Rehm BHA; Centre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, 4111, Australia. b.rehm@griffith.edu.au.; Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia. b.rehm@griffith.edu.au.
Jazyk: angličtina
Zdroj: NPJ vaccines [NPJ Vaccines] 2023 Sep 07; Vol. 8 (1), pp. 133. Date of Electronic Publication: 2023 Sep 07.
DOI: 10.1038/s41541-023-00727-6
Abstrakt: Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella burnetii. Transmission occurs from livestock to humans through inhalation of a survival form of the bacterium, the Small Cell Variant, often via handling of animal parturition products. Q fever manifests as an acute self-limiting febrile illness or as a chronic disease with complications such as vasculitis and endocarditis. The current preventative human Q fever vaccine Q-VAX poses limitations on its worldwide implementation due to reactogenic responses in pre-sensitized individuals. Many strategies have been undertaken to develop a universal Q fever vaccine but with little success to date. The mechanisms of the underlying reactogenic responses remain only partially understood and are important factors in the development of a safe Q fever vaccine. This review provides an overview of previous and current experimental vaccines developed for use against Q fever and proposes approaches to develop a vaccine that establishes immunological memory while eliminating harmful reactogenic responses.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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