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| Grant Information: |
RVO Institute of Biotechnology of the Czech Academy of Sciences v.v.i., Institutional Research Concept; 86652036 Institute of Biotechnology of the Czech Academy of Sciences v.v.i., Institutional Research Concept; 2021R1C1C1006336 Basic Science Research Program, South Korea; 2021M3A9G8022959 Bio & Medical Technology Development Program of the Ministry of Science, ICT (NRF), South Korea |
| Contributed Indexing: |
Keywords: caffeine; caffeinism; health; molecular receptors; pharmacology |
| Substance Nomenclature: |
3G6A5W338E (Caffeine) |
| Entry Date(s): |
Date Created: 20230907 Date Completed: 20231216 Latest Revision: 20231216 |
| Update Code: |
20231217 |
| DOI: |
10.1002/ptr.8000 |
| PMID: |
37679309 |
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| Autor: |
Song X; Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China., Kirtipal N; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Lee S; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea., Malý P; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences v.v.i, BIOCEV Research Center, Vestec, Czech Republic., Bharadwaj S; Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences v.v.i, BIOCEV Research Center, Vestec, Czech Republic. |
| Jazyk: |
angličtina |
| Zdroj: |
Phytotherapy research : PTR [Phytother Res] 2023 Dec; Vol. 37 (12), pp. 5558-5598. Date of Electronic Publication: 2023 Sep 07. |
| DOI: |
10.1002/ptr.8000 |
| Abstrakt: |
Caffeine, which shares consubstantial structural similarity with purine adenosine, has been demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the biological functions at physiologically relevant dosages. Accumulating evidence supports caffeine's beneficial effects against different disorders, such as total cardiovascular diseases and type 2 diabetes. Conversely, paradoxical effects are also linked to caffeine ingestion in humans including hypertension-hypotension and tachycardia-bradycardia. These observations suggest the association of caffeine action with its ingested concentration and/or concurrent interaction with preferential molecular targets to direct explicit events in the human body. Thus, a coherent analysis of the functional targets of caffeine, relevant to normal physiology, and disease pathophysiology, is required to understand the pharmacology of caffeine. This review provides a broad overview of the experimentally validated targets of caffeine, particularly those of therapeutic interest, and the impacts of caffeine on organ-specific physiology and pathophysiology. Overall, the available empirical and epidemiological evidence supports the dose-dependent functional activities of caffeine and advocates for further studies to get insights into the caffeine-induced changes under specific conditions, such as asthma, DNA repair, and cancer, in view of its therapeutic applications.
(© 2023 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.) |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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