Engineered adult stem cells: Current clinical trials status of disease treatment.

Autor:	Han P; Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia; The University of Queensland, School of Dentistry, Brisbane, QLD, Australia., Moran CS; Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia; The University of Queensland, School of Dentistry, Brisbane, QLD, Australia., Liu C; Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia; The University of Queensland, School of Dentistry, Brisbane, QLD, Australia., Griffiths R; Australian Red Cross Lifeblood, Brisbane, QLD, Australia., Zhou Y; Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia; The University of Queensland, School of Dentistry, Brisbane, QLD, Australia. Electronic address: yinghong.zhou@uq.edu.au., Ivanovski S; Center for Oral-facial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, QLD, Australia; The University of Queensland, School of Dentistry, Brisbane, QLD, Australia. Electronic address: s.ivanovski@uq.edu.au.
Jazyk:	angličtina
Zdroj:	Progress in molecular biology and translational science [Prog Mol Biol Transl Sci] 2023; Vol. 199, pp. 33-62. Date of Electronic Publication: 2023 Jul 26.
DOI:	10.1016/bs.pmbts.2023.02.007
Abstrakt:	Regenerative medicine is an interdisciplinary field involving the process of replacing and regenerating cells/tissues or organs by integrating medicine, science, and engineering principles to enhance the intrinsic regenerative capacity of the host. Recently, engineered adult stem cells have gained attention for their potential use in regenerative medicine by reducing inflammation and modulating the immune system. This chapter introduces adult stem cell engineering and chimeric antigen receptor T cells (CAR T) gene therapy and summarises current engineered stem cell- and extracellular vesicles (EVs)-focused clinical trial studies that provide the basis for the proposal of a personalised medicine approach to diseases diagnosis and treatment. (Copyright © 2023. Published by Elsevier Inc.)
Databáze:	MEDLINE
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