Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment-resistant depression following electroconvulsive therapy.

Autor: Xu SX; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Xie XH; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Yao L; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Wang W; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Zhang H; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Chen MM; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Sun S; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Nie ZW; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Nagy C; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Liu Z; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.
Jazyk: angličtina
Zdroj: Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2023 Dec; Vol. 77 (12), pp. 653-664. Date of Electronic Publication: 2023 Oct 11.
DOI: 10.1111/pcn.13596
Abstrakt: Aim: The current study aimed to investigate the neuroinflammatory hypothesis of depression and the potential anti-inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing astrocyte-derived extracellular vesicles (ADEVs) isolated from plasma.
Methods: A total of 40 patients with treatment-resistant depression (TRD) and 35 matched healthy controls were recruited at baseline, and 34 patients with TRD completed the post-ECT visits. Blood samples were collected at baseline and post-ECT. Plasma ADEVs were isolated and confirmed, and the concentrations of two astrocyte markers (glial fibrillary acidic protein [GFAP] and S100β), an extracellular vesicle marker cluster of differentiation 81 (CD81), and nine inflammatory markers in ADEVs were measured as main analyses. In addition, correlation analysis was conducted between clinical features and ADEV protein levels as exploratory analysis.
Results: At baseline, the TRD group exhibited significantly higher levels of two astrocyte markers GFAP and S100β, as well as CD81 compared with the healthy controls. Inflammatory markers interferon γ (IFN-γ), interleukin (IL) 1β, IL-4, IL-6, tumor necrosis factor α, IL-10, and IL-17A were also significantly higher in the TRD group. After ECT, there was a significant reduction in the levels of GFAP, S100β, and CD81, along with a significant decrease in the levels of IFN-γ and IL-4. Furthermore, higher levels of GFAP, S100β, CD81, and inflammatory cytokines were associated with more severe depressive symptoms and poorer cognitive function.
Conclusion: This study provides direct insight supporting the astrocyte activation and neuroinflammatory hypothesis of depression using ADEVs. ECT may exert an anti-inflammatory effect through inhibition of such activation of astrocytes.
(© 2023 The Authors. Psychiatry and Clinical Neurosciences © 2023 Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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