Trabecular bone density in middle-aged women with reproductive disorders.

Autor:	van Zwol-Janssens C; C van Zwol - Janssens, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands., Hage A; A Hage, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands., van der Ham K; K van der Ham, Department of Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, Netherlands., Velthuis BK; B Velthuis, Department of Radiology, UMC Utrecht, Utrecht, Netherlands., Budde RPJ; R Budde, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands., Koster MPH; M Koster, Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, Netherlands., Franx A; A Franx, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands., Fauser BCJM; B Fauser, Department of Reproductive Medicine and Gynecology, UMC Utrecht, Utrecht, Netherlands., Boersma E; E Boersma, Cardiology, Erasmus MC, Rotterdam, Netherlands., Bos D; D Bos, Department of Radiology and Nuclear Medicine and Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands., Laven JSE; J Laven, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands., Louwers YV; Y Louwers, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	Endocrine connections [Endocr Connect] 2023 Sep 01. Date of Electronic Publication: 2023 Sep 01.
DOI:	10.1530/EC-23-0166
Abstrakt:	Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (PE) are expected to have normal estrogen exposure. Within the CREw-IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with an reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) -26.8, 95% confidence interval (CI) -37.2 - -16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3 - 25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD.
Databáze:	MEDLINE
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