The Effect of Statins on Mortality of Patients With Chronic Kidney Disease Based on Data of the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) and Korea National Health Insurance Claims Database.
Autor: | Kim JE; Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea., Choi YJ; Biomedical Research Institute, Korea University Guro Hospital, Seoul, South Korea., Oh SW; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Korea University Anam Hospital, Seoul, South Korea., Kim MG; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Korea University Anam Hospital, Seoul, South Korea., Jo SK; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Korea University Anam Hospital, Seoul, South Korea., Cho WY; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Korea University Anam Hospital, Seoul, South Korea., Ahn SY; Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea., Kwon YJ; Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea., Ko GJ; Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.; Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in nephrology [Front Nephrol] 2022 Feb 02; Vol. 1, pp. 821585. Date of Electronic Publication: 2022 Feb 02 (Print Publication: 2021). |
DOI: | 10.3389/fneph.2021.821585 |
Abstrakt: | The role of statins in chronic kidney disease (CKD) has been extensively evaluated, but it remains controversial in specific population such as dialysis-dependent CKD. This study examined the effect of statins on mortality in CKD patients using two large databases. In data from the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) from two hospitals, CKD was defined as an estimated glomerular filtration rate < 60 mL/min/m 2 ; we compared survival between patients with or without statin treatment. As a sensitivity analysis, the results were validated with the Korea National Health Insurance (KNHI) claims database. In the analysis of CDM datasets, statin users showed significantly lower risks of all-cause and cardiovascular mortality in both hospitals, compared to non-users. Similar results were observed in CKD patients from the KNHI claims database. Lower mortality in the statin group was consistently evident in all subgroup analyses, including patients on dialysis and low-risk young patients. In conclusion, we found that statins were associated with lower mortality in CKD patients, regardless of dialysis status or other risk factors. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Kim, Choi, Oh, Kim, Jo, Cho, Ahn, Kwon and Ko.) |
Databáze: | MEDLINE |
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