Curcumin Attenuates Nonylphenol-Induced Toxicity In Brain Development; An Experimental Study.

Autor:	Suna PA; Department of Histology and Embryology, Erciyes University, Faculty of Medicine, Kayseri, Turkey., Gergin OO; Department of Anesthesiology and Reanimation, Erciyes University, Faculty of Medicine, Kayseri, Turkey., Baran M; Department of Pharmaceutical Basic Science, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey., Ulger M; Department of Histology and Embryology, Erciyes University, Faculty of Medicine, Kayseri, Turkey., Goc R; Sivas Cumhuriyet University, Department of Histology and Embryology, Faculty of Medicine, Sivas, Turkey., Yay A; Department of Histology and Embryology, Erciyes University, Faculty of Medicine, Kayseri, Turkey;Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.
Jazyk:	angličtina
Zdroj:	Acta neurologica Taiwanica [Acta Neurol Taiwan] 2023 Sep 30; Vol. 32(3), pp. 100-107.
Abstrakt:	Objective: Nonylphenol is an alkylphenol compound that has been widely used in the industry. It has endocrine-disrupting properties. The effect of alkylphenol compounds on development has been the subject of a limited number of studies. Herein, we aimed to examine curcumin's effect against nonylphenol toxicity on brain development. Methods: For this study, 30 pregnant female Wistar albino rats from the Animal Laboratory of Erciyes University, Faculty of Medicine, were used. The rats were randomly divided into the following 5 groups; the control group, corn oil group (150μl/kg/day), nonylphenol group (50μl/kg/day), curcumin group (100mg/kg/day) and curcumin+nonylphenol group (100mg/kg/day+50 μl/kg/day). After the sacrification, histological and immunohistochemical evaluations were made. Results: Histopathologically, vascular congestion, increased GFAP, and p-tau immunoreactivity intensity was found in the developing brain of the nonylphenol group. Moreover, co-treatment of nonylphenol administrated with curcumin showed slight pathological alterations with vascular congestion. Conclusions: These data suggest that nonylphenol-induced increase in GFAP and p-tau immunoreactivity contributes to toxicity caused impairment in the rat brain. Additionally, curcumin had a neuroprotective effect against nonylphenol-induced neurotoxicity.
Databáze:	MEDLINE
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