Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction.

Autor: Feka J; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Jomrich G; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Winkler D; Department of Statistics and Operations Research, University of Vienna, Oskar Morgenstern Platz 1, 1090, Vienna, Austria., Ilhan-Mutlu A; Department of Medicine 1, Comprehensive Cancer Center (CCC), Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Kristo I; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Paireder M; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Rieder E; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Bologheanu M; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Asari R; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria., Schoppmann SF; Department of Surgery, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria. sebastian.schoppmann@meduniwien.ac.at.; Upper-GI Unit, Department of Surgery, Division of General Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. sebastian.schoppmann@meduniwien.ac.at.
Jazyk: angličtina
Zdroj: Langenbeck's archives of surgery [Langenbecks Arch Surg] 2023 Sep 06; Vol. 408 (1), pp. 351. Date of Electronic Publication: 2023 Sep 06.
DOI: 10.1007/s00423-023-03093-y
Abstrakt: Objective: The aim of this study was to investigate the prognostic role of plasma platelet count (PLT), mean platelet volume (MPV), and the combined COP-MPV score in patients with resectable adenocarcinomas of the gastroesophageal junction.
Background: Platelet activation, quantified by PLT and elevated MPV, plays an essential part in the biological process of carcinogenesis and metastasis. An increased preoperative COP-MPV is associated with poor survival in various tumor entities.
Methods: Data of 265 patients undergoing surgical resection for adenocarcinoma of the gastroesophageal junction were abstracted. COP-MPV score was defined for each patient. Utilizing univariate and multivariate Cox proportional hazard analyses, survival was determined.
Results: In univariate analysis, elevated PLT (HR 3.58, 95% CI 2.61-4.80, p<0.001) and increased COP-MPV (HR 0.27, 95% CI 0.17-0.42, p<0.001 and HR 0.42, 95% CI 0.29-0.60, p<0.001) significantly correlated with shorter patients' overall and disease-free survival, for all 256 patients, as well as in the subgroups of neoadjuvantly treated (p<0.001) and primarily resected patients (p<0.001). COP-MPV remained a significant prognostic factor in multivariate analysis for OS. However, PLT alone showed significant diminished OS and DFS in all subgroups (p<0.001) in univariate and multivariate analysis.
Conclusion: PLT is a potent independent prognostic biomarker for survival in a large prospective cohort of patients with resectable adenocarcinoma of the gastroesophageal junction. Additionally, we confirm that the COP-MPV score is significantly associated with worse outcome in these patients, but has no benefit in comparison to PLT.
(© 2023. The Author(s).)
Databáze: MEDLINE
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