Depression recurrence is accompanied by longer periods in default mode and more frequent attentional and reward processing dynamic brain-states during resting-state activity.

Autor: Alonso S; Department of Biomedical Sciences of Cells and Systems, Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Clinical Medicine, Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Tyborowska A; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands., Ikani N; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.; Depression Expertise Center, ProPersona Mental Health Care, Nijmegen, the Netherlands.; Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Pro Persona Mental Health Care, Nijmegen, the Netherlands., Mocking RJT; Department of Psychiatry, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands., Figueroa CA; Department of Psychiatry, University Medical Centre Utrecht, Utrecht, the Netherlands.; School of Social Welfare, University of California, Berkeley, California, USA., Schene AH; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands., Deco G; Department of Information and Communication Technologies, Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain.; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Kringelbach ML; Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK.; Center for Music in the Brain, Aarhus University, Aarhus, Denmark.; Department of Psychiatry, University of Oxford, Oxford, UK., Cabral J; Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal., Ruhé HG; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands.
Jazyk: angličtina
Zdroj: Human brain mapping [Hum Brain Mapp] 2023 Dec 01; Vol. 44 (17), pp. 5770-5783. Date of Electronic Publication: 2023 Sep 06.
DOI: 10.1002/hbm.26475
Abstrakt: Recurrence in major depressive disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire changes after patients transition from remission to recurrence of a new depressive episode. Sixty two drug-free, MDD-patients with ≥2 episodes underwent a baseline resting-state fMRI scan when in remission. Over 30-months follow-up, 11 patients with a recurrence and 17 matched-remitted MDD-patients without a recurrence underwent a second fMRI scan. Recurrent patterns of functional connectivity were characterized by applying Leading Eigenvector Dynamics Analysis (LEiDA). Differences between baseline and follow-up were identified for the 11 non-remitted patients, while data from the 17 matched-remitted patients was used as a validation dataset. After the transition into a depressive state, basal ganglia-anterior cingulate cortex (ACC) and visuo-attentional networks were detected significantly more often, whereas default mode network activity was found to have a longer duration. Additionally, the fMRI signal in the basal ganglia-ACC areas underlying the reward network, were significantly less synchronized with the rest of the brain after recurrence (compared to a state of remission). No significant changes were observed in the matched-remitted patients who were scanned twice while in remission. These findings characterize changes that may be associated with the transition from remission to recurrence and provide initial evidence of altered dynamical exploration of the brain's repertoire of functional networks when a recurrent depressive episode occurs.
(© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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