Prognostic value of illness perception on changes in knee pain among elderly individuals: Two-year results from the Frederiksberg Cohort study.
| Autor: | Ginnerup-Nielsen E; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark., Christensen R; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark., Heitmann BL; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Section for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Altman RD; Division of Rheumatology and Immunology, University of California, Los Angeles, CA 90095, USA., March L; Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, and Kolling Institute; and Sydney Muskuloskeletal Health, University of Sydney, NSW Australia., Woolf A; Bone and Joint Research Group, Royal Cornwall Hospital, Truro TR1 3HD, UK., Bliddal H; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark., Henriksen M; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2023 Aug 19; Vol. 5 (4), pp. 100403. Date of Electronic Publication: 2023 Aug 19 (Print Publication: 2023). |
| DOI: | 10.1016/j.ocarto.2023.100403 |
| Abstrakt: | Objective: To investigate the prognostic value of illness perception (IP) on knee pain, quality of life (QoL) and functional level in elderly individuals reporting knee pain. Design: A prospective cohort study of 1552 elderly with knee pain comparing two previously established clusters based on the Brief Illness Perception questionnaire. Cluster 1 ("Concerned optimists" [hypothesized unfavorable profile]; n = 642) perceived their knee pain as a greater threat to them than Cluster 2 ("Unconcerned confident" [hypothesized favorable profile]; n = 910). Primary outcome was the change from baseline to year 2 in the KOOS Pain subscale. Secondary outcomes were changes from baseline in quality of life (EuroQol-5 Domain and EQ VAS) and in the KOOS subscales Symptom, Activities of Daily Living, Knee-related QoL and Sports and recreation. Analyses were done on the original Intention-To-Survey (ITS) population, using repeated measures mixed linear models. Results: Among the ITS population, 841 (54%) responded to the 2-year survey. There was a statistically significant but clinically irrelevant cluster difference in the 2-year change from baseline in KOOS pain (mean difference: 6.0 KOOS points [95% CI: 7.3 to -4.7]) explained by a minor improvement in Cluster 1: (6.2 points) and no changes in Cluster 2: (0.2 points). Comparable results were found across the secondary outcomes. Clinically irrelevant cluster changes in IP were seen. Conclusion: In a cohort of people with knee pain, IP phenotype (i.e., Clusters) were of no prognostic value for the 2-year changes in pain, function, and QoL. Targeting IP may not be relevant in this patient population. Trial Registration Number and Date of Registration: The Frederiksberg Cohort study was pre-registered at clinicaltrials.gov (NCT03472300) on March 21, 2018. Competing Interests: All authors have completed the Osteoarthritis and Cartilage Open authors’ disclosure form and declare that they have no competing interests to report. (© 2023 The Author(s).) |
| Databáze: | MEDLINE |
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