Mechanisms of fibrous cap formation in atherosclerosis.
| Autor: | Alonso-Herranz L; Atherosclerosis Research Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Albarrán-Juárez J; Atherosclerosis Research Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Bentzon JF; Atherosclerosis Research Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Steno Diabetes Center Aarhus and Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 Aug 21; Vol. 10, pp. 1254114. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023). |
| DOI: | 10.3389/fcvm.2023.1254114 |
| Abstrakt: | The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death. Therefore, the qualities of the cap are primary determinants of the clinical outcome of coronary and carotid atherosclerosis. In this mini-review, we discuss current knowledge about the formation of the fibrous cap, including cell recruitment, clonal expansion, and central molecular signaling pathways. We also examine the differences between mouse and human fibrous caps and explore the impact of anti-atherosclerotic therapies on the state of the fibrous cap. We propose that the cap should be understood as a neo-media to substitute for the original media that becomes separated from the surface endothelium during atherogenesis and that embryonic pathways involved in the development of the arteria media contribute to cap formation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Alonso-Herranz, Albarrán-Juárez and Bentzon.) |
| Databáze: | MEDLINE |
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