The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications.

Autor:	Silva JMC; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil., Teixeira EB; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil., Mourão RMDS; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil., Ferraz RS; Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belem, Pará, Brazil., Moreira FC; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil., de Assumpção PP; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil., Calcagno DQ; Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2023 Aug 21; Vol. 14, pp. 1237723. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023).
DOI:	10.3389/fphar.2023.1237723
Abstrakt:	Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Silva, Teixeira, Mourão, Ferraz, Moreira, Assumpção and Calcagno.)
Databáze:	MEDLINE
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