Strong Protein Adhesives through Lanthanide-enhanced Structure Folding and Stack Density.

Autor: Chen J; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China., Shi W; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China., Ren Y; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China., Zhao K; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Liu Y; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.; College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China., Jia B; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Zhao L; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Li M; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Liu Y; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Su J; College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China., Ma C; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China., Wang F; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Sun J; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China., Tian Y; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China., Li J; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China., Zhang H; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; Xiangfu Laboratory, Jiaxing, 314102, China., Liu K; Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.; Xiangfu Laboratory, Jiaxing, 314102, China.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Oct 23; Vol. 62 (43), pp. e202304483. Date of Electronic Publication: 2023 Sep 18.
DOI: 10.1002/anie.202304483
Abstrakt: Generating strong adhesion by engineered proteins has the potential for high technical applications. Current studies of adhesive proteins are primarily limited to marine organisms, e.g., mussel adhesive proteins. Here, we present a modular engineering strategy to generate a type of exotic protein adhesives with super strong adhesion behaviors. In the protein complexes, the lanmodulin (LanM) underwent α-helical conformational transition induced by lanthanides, thereby enhancing the stacking density and molecular interactions of adhesive protein. The resulting adhesives exhibited outstanding lap-shear strength of ≈31.7 MPa, surpassing many supramolecular and polymer adhesives. The extreme temperature (-196 to 200 °C) resistance capacity and underwater adhesion performance can significantly broaden their practical application scenarios. Ex vivo and in vivo experiments further demonstrated the persistent adhesion performance for surgical sealing and healing applications.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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