Design strategy and research progress of multifunctional nanoparticles in lung cancer therapy.

Autor:	Min SH; Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Lei W; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Jun CJ; Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Yan ZS; Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Guang YX; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Tong Z; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Yong ZP; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Hui LZ; Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Xing H; Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2023 Jul-Dec; Vol. 32 (8), pp. 723-739. Date of Electronic Publication: 2023 Sep 05.
DOI:	10.1080/13543784.2023.2254683
Abstrakt:	Introduction: Lung cancer is one of the cancer types with the highest mortality rate, exploring a more effective treatment modality that improves therapeutic efficacy while mitigating side effects is now an urgent requirement. Designing multifunctional nanoparticles can be used to overcome the limitations of drugs and conventional drug delivery systems. Nanotechnology has been widely researched, and through different needs, suitable nanocarriers can be selected to load anti-cancer drugs to improve the therapeutic effect. It is foreseeable that with the rapid development of nanotechnology, more and more lung cancer patients will benefit from nanotechnology. This paper reviews the merits of various multifunctional nanoparticles in the treatment of lung cancer to provide novel ideas for lung cancer treatment. Areas Covered: This review focuses on summarizing various nanoparticles for targeted lung cancer therapy and their advantages and disadvantages, using nanoparticles loaded with anti-cancer drugs, delivered to lung cancer sites, enhancing drug half-life, improving anti-cancer drug efficacy and reducing side effects. Expert Opinion: The delivery mode of nanoparticles with superior pharmacokinetic properties in the in vivo circulation enhances the half-life of the drug, and provides tissue-targeted selectivity and the ability to overcome biological barriers, bringing a revolution in the field of oncology.
Databáze:	MEDLINE
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