[Clinical characteristics, pathology, and prognosis of children with diffuse endocapillary proliferative Henoch-Schönlein purpura nephritis].

Autor:	Yin TT; Department of Nephrology, Jiangxi Provincial Children's Hospital, Nanchang 330006, China., Peng XJ; Department of Nephrology, Jiangxi Provincial Children's Hospital, Nanchang 330006, China., Fu R; Department of Nephrology, Jiangxi Provincial Children's Hospital, Nanchang 330006, China., Wang Y, Lyu Y, Deng YQ, Fu JQ, Zhang ZH
Jazyk:	čínština
Zdroj:	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2023 Aug 15; Vol. 25 (8), pp. 837-842.
DOI:	10.7499/j.issn.1008-8830.2303022
Abstrakt:	Objectives: To investigate the clinical characteristics, pathology, and prognosis of children with diffuse endocapillary proliferative Henoch-Schönlein purpura nephritis (DEP-HSPN). Methods: A retrospective analysis was performed on the clinical, pathological, and prognosis data of 44 children with DEP-HSPN and 765 children without DEP-HSPN. The children with DEP-HSPN were diagnosed by renal biopsy in Jiangxi Provincial Children's Hospital from January 2006 to December 2021. Results: Among the 809 children with purpura nephritis, 44 (5.4%) had DEP-HSPN, with a mean age of (8±3) years, and there were 29 boys (65.9%) and 15 girls (34.1%). Compared with the non-DEP-HSPN group, the DEP-HSPN group had a significantly shorter time from onset to renal biopsy and a significantly higher proportion of children with respiratory infection or gross hematuria, and most children had nephrotic syndrome. The DEP-HSPN group had significantly higher levels of 24-hour urinary protein, urinary protein grading, microscopic hematuria grading, serum creatinine, and blood urea nitrogen and significantly lower levels of serum albumin and complement C3 ( P <0.05). The DEP-HSPN group had a higher pathological grading, with predominant deposition of IgA in the mesangial area and capillary loops, and higher activity scores in the modified semi-quantitative scoring system ( P <0.05). The Kaplan-Meier survival analysis showed that there was no significant difference in the renal complete remission rate between the two groups ( P >0.05). Conclusions: Children with DEP-HSPN have a rapid onset, severe clinical manifestations and pathological grading, and high activity scores in the modified semi-quantitative scoring system. However, most of the children with DEP-HSPN have a good prognosis, with a comparable renal complete remission rate to the children without DEP-HSPN.
Databáze:	MEDLINE
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