Antidepressant properties of voluntary exercise mediated by gut microbiota.

Autor:	Watanabe C; Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Oyanagi E; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Aoki T; Department of Clinical Nutrition, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Hamada H; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Kawashima M; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Yamagata T; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Kremenik MJ; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan., Yano H; Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan.; Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan.
Jazyk:	angličtina
Zdroj:	Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2023 Oct 25; Vol. 87 (11), pp. 1407-1419.
DOI:	10.1093/bbb/zbad115
Abstrakt:	Although regular exercise has been reported to prevent depression, it has not been clarified whether the gut microbiota is involved in the factors that prevent depression through exercise. We investigated the effects of voluntary exercise on the gut microbiota and the prevention of depression-like behaviors using mice. C57BL/6 J male mice were subjected to 10 weeks of sedentary control or wheel running, then they were subjected to social defeat stress (SDS). Exercise attenuated that sucrose drinking was decreased by SDS treatment. Exercise increased the expression of Bdnf and decreased expression of Zo-1 and Claudin5 in the brain. Fecal Turicibacter, Allobaculum, and Clostridium sensu stricto, and propionate in the cecum were decreased by the exercise. Voluntary exercise-induced antidepressant properties might be partially caused by suppression of serotonin uptake into gut microbiota and increase the permeability of the blood-brain barrier via reduced propionate production. (© The Author(s) 2023. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Databáze:	MEDLINE
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