Decreased plasma cartilage acidic protein 1 in COVID-19.

Autor: Johansson MW; Morgridge Institute for Research, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Balnis J; Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, New York, USA.; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA., Muehlbauer LK; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Bukhman YV; Morgridge Institute for Research, Madison, Wisconsin, USA., Stefely MS; Morgridge Institute for Research, Madison, Wisconsin, USA., Overmyer KA; Morgridge Institute for Research, Madison, Wisconsin, USA.; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA., Vancavage R; Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, New York, USA.; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA., Tiwari A; Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, New York, USA.; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA., Adhikari AR; Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, New York, USA.; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA., Feustel PJ; Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA., Schwartz BS; Morgridge Institute for Research, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Coon JJ; Morgridge Institute for Research, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Stewart R; Morgridge Institute for Research, Madison, Wisconsin, USA., Jaitovich A; Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, New York, USA.; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA., Mosher DF; Morgridge Institute for Research, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2023 Sep; Vol. 11 (17), pp. e15814.
DOI: 10.14814/phy2.15814
Abstrakt: Cartilage acidic protein-1 (CRTAC1) is produced by several cell types, including Type 2 alveolar epithelial (T2AE) cells that are targeted by SARS-CoV2. Plasma CRTAC1 is known based on proteomic surveys to be low in patients with severe COVID-19. Using an ELISA, we found that patients treated for COVID-19 in an ICU almost uniformly had plasma concentrations of CRTAC1 below those of healthy controls. Magnitude of decrease in CRTAC1 distinguished COVID-19 from other causes of acute respiratory decompensation and correlated with established metrics of COVID-19 severity. CRTAC1 concentrations below those of controls were found in some patients a year after hospitalization with COVID-19, long COVID after less severe COVID-19, or chronic obstructive pulmonary disease. Decreases in CRTAC1 in severe COVID-19 correlated (r = 0.37, p = 0.0001) with decreases in CFP (properdin), which interacts with CRTAC1. Thus, decreases of CRTAC1 associated with severe COVID-19 may result from loss of production by T2AE cells or co-depletion with CFP. Determination of significance of and reasons behind decreased CRTAC1 concentration in a subset of patients with long COVID will require analysis of roles of preexisting lung disease, impact of prior acute COVID-19, age, and other confounding variables in a larger number of patients.
(© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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