Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients.

Autor: Faustine I; Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia.; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, 94148, Central Sulawesi, Indonesia., Marteka D; Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia., Malik A; Division of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia. amarila.malik@ui.ac.id., Supriyanto E; Department of Biomedical Engineering & Health Science, Universiti Teknologi Malaysia, Johor Bahru, Johor, 81310, Malaysia., Syafhan NF; Division of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia.; Universitas Indonesia Hospital, Jl. Prof. Dr. Bahder Djohan, Pondok Cina, Depok, 16424, West Java, Indonesia.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2023 Sep 04; Vol. 16 (1), pp. 194. Date of Electronic Publication: 2023 Sep 04.
DOI: 10.1186/s13104-023-06483-z
Abstrakt: Objective: Genetic polymorphisms in ACE and ACE2 genes are involved in the RAS regulation of blood pressure and their activity may confer susceptibility to hypertension. In addition, they may play a role in SARS-CoV-2 pathogenesis and the severity of COVID-19. This study aims to determine the effect of genetic variations in the ACE (rs4331) and ACE2 (rs2074192) genes with hypertension comorbidity on the severity of COVID-19 in the Indonesian population.
Result: 186 patients were enrolled and assigned into the COVID-19 group (n = 95) and non-COVID-19 group (n = 91) in this cross-sectional study. GG genotype frequency was dominant in ACE gene, but there were no significant differences between the groups (p = 0.163). The two groups had a significant difference (p = 0.000) for the CC genotype frequency (0,37 vs. 0.01) in the ACE2 gene. The proportion of women with COVID-19 is higher (51%), but men with hypertension had more severe symptoms (44%). Men with hypertension comorbidity, GG (ACE), and TT (ACE2) genotypes tended to have moderate-to-severe symptoms (25%). Similarly, women with hypertension as well as GG and CT genotypes tended to have moderate-to-severe symptoms (21%). We conclude that hypertension and mutations in the ACE (rs4331) and ACE2 (rs2074192) genes affect the severity of COVID-19.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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