| Autor: |
Li MJ; Department of Medical Examination, the Beijing Institute of Occupational Disease Prevention and Treatment Beijing Prevention and Treatment Hospital of Occupational Disease for Chemical Industry, Beijing 100093, China., Li J; Department of Medical Examination, the Beijing Institute of Occupational Disease Prevention and Treatment Beijing Prevention and Treatment Hospital of Occupational Disease for Chemical Industry, Beijing 100093, China., Niu DS; Department of Medical Examination, the Beijing Institute of Occupational Disease Prevention and Treatment Beijing Prevention and Treatment Hospital of Occupational Disease for Chemical Industry, Beijing 100093, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2023 Aug 20; Vol. 41 (8), pp. 636-640. |
| DOI: |
10.3760/cma.j.cn121094-20230302-00059 |
| Abstrakt: |
The cell nuclear damage is mainly caused by the radiation and various carcinogenic compounds, the essence of the damage is molecular adhesion fracture and chemical modification. After nuclear damage, the cells whose nuclei may be abnormal in morphology, structure and function, then become a kind of morbid cells or defective cells. The cell nuclear damage can affect gene expression and regulation, leading to dysfunctions or abnormalities of transcription and protein synthesis, which results in aging and induces various chronic refractory diseases, such as hypertension, atherosclerosis, diabetes, Alzheimer's disease, autoimmune diseases, and so on. The cell nuclear damage can also affect the state of cell differentiation and lead to restart of genes related to division and proliferation, thus inducing cancer. The cancer cells are derived from the cells with nuclear abnormalities, and the biological behavior or characteristics of cancer cells (shedding and metastasis, immune tolerance, uncontrolled, loss of contact inhibition, etc.) are derived from cells with nuclear abnormalities. This article reviewed the chronic refractory diseases caused by nuclear damage and their mechanisms, which provided a new idea for occupational health and toxicology research, as well as a new method and strategy for occupational disease prevention and treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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