Application of nanomaterials as potential quorum quenchers for disease: Recent advances and challenges.

Autor: Alghamdi S; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Khandelwal K; Department of Life Sciences, School of Basic Sciences and Research, Sharda University Greater Noida, India., Pandit S; Department of Life Sciences, School of Basic Sciences and Research, Sharda University Greater Noida, India., Roy A; Department of Biotechnology, Sharda School of Engineering & Technology, Sharda University, Greater Noida, India. Electronic address: arbt2014@gmail.com., Ray S; Department of Life Sciences, School of Basic Sciences and Research, Sharda University Greater Noida, India., Alsaiari AA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Aljuaid A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Almehmadi M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Allahyani M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia., Sharma R; Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India., Anand J; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India., Alshareef AA; Laboratory and Blood Bank Department, Alnoor Specialist Hospital, Ministry of Health, Makkah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2023 Nov; Vol. 184, pp. 13-31. Date of Electronic Publication: 2023 Sep 02.
DOI: 10.1016/j.pbiomolbio.2023.08.005
Abstrakt: Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as "quorum quenching" (QQ) disrupts microbial communication. Numerous techniques, including colorimetry, electrochemistry, bioluminescence, chemiluminescence, fluorescence, chromatography-mass spectroscopy, and many more, can be used to test QS/QQ. They all permit quantitative and qualitative measurements of QS/QQ molecules. The mechanism of QS and QQ, as well as the use of QQ in the prevention of biofilms, are all elaborated upon in this writing, along with the fundamental study of nanoparticle (NP)in QQ. Q.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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