| Autor: |
Xu FF; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China., Jian JZ; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China., Li YJ; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China., Wang ZW; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China., Luo GY; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China., Yang WD; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People's Republic of China. |
| Abstrakt: |
Two new 2-arylbenzo[ b ]furans ( 1 - 2 ) and ten known compounds ( 3 - 12 ) were identified from the 95% EtOH extract of the branches and leaves of Itea indochinensis for the first time. Their structures were determined mainly based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. The results of MTT assays demonstrated the anti-tumor potential of compound 1 with good selectivity, which displayed moderate inhibitory effects on proliferation of SK-hep-1 cells with IC 50 value of 22.3 μM, while weak inhibitory effect on proliferation of HepG2 cells with an inhibition rate of 25% at 20 μM, and no obviously inhibitory effect on proliferation of A549 cells at 20 μM. In addition, compound 1 exhibited its significant scavenging capacity on ABTS ·+ free radical with an IC 50 value of 0.11 mg/mL, while weak scavenging effects on DPPH and O 2 ·- radicals with scavenging ratios of 32.93% and 21.49% at 1 mg/mL, respectively. |
