MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae .

Autor:	Galli M; Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany., Jacob S; Institute of Biotechnology and Drug Research GmbH, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany., Zheng Y; Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany., Ghezellou P; Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany., Gand M; Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany., Albuquerque W; Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany., Imani J; Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany., Allasia V; Université Côte d'Azur, INRAE, CNRS, UMR1355-7254, ISA, 06903 Sophia Antipolis, France., Coustau C; Université Côte d'Azur, INRAE, CNRS, UMR1355-7254, ISA, 06903 Sophia Antipolis, France., Spengler B; Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392, Giessen, Germany., Keller H; Université Côte d'Azur, INRAE, CNRS, UMR1355-7254, ISA, 06903 Sophia Antipolis, France., Thines E; Institute of Biotechnology and Drug Research GmbH, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany.; Johannes Gutenberg-University Mainz, Microbiology and Biotechnology at the Institute of Molecular Physiology, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany., Kogel KH; Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2023 Aug 06; Vol. 26 (9), pp. 107565. Date of Electronic Publication: 2023 Aug 06 (Print Publication: 2023).
DOI:	10.1016/j.isci.2023.107565
Abstrakt:	Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with chemotactic, pro-inflammatory, and growth-promoting activities first discovered in mammals. In parasites, MIF homologs are involved in immune evasion and pathogenesis. Here, we present the first comprehensive analysis of an MIF protein from the devastating plant pathogen Magnaporthe oryzae ( Mo ). The fungal genome encodes a single MIF protein ( Mo MIF1) that, unlike the human homolog, harbors multiple low-complexity regions (LCRs) and is unique to Ascomycota. Following infection, MoMIF1 is expressed in the biotrophic phase of the fungus, and is strongly down-regulated during subsequent necrotrophic growth in leaves and roots. We show that Mo MIF1 is secreted during plant infection, affects the production of the mycotoxin tenuazonic acid and inhibits plant cell death. Our results suggest that Mo MIF1 is a novel key regulator of fungal virulence that maintains the balance between biotrophy and necrotrophy during the different phases of fungal infection. Competing Interests: The authors declare no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
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