Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep.

Autor:	Benavides-Lara J; Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States., Manwar R; Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States., McGuire LS; Department of Neurological Surgery, University of Illinois at Chicago - College of Medicine, Chicago, IL, United States., Islam MT; Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States., Shoo A; Section of Neonatology, Department of Pediatrics, UIHealth Children's Hospital of the University of Illinois at Chicago, Chicago, IL, United States., Charbel FT; Department of Neurological Surgery, University of Illinois at Chicago - College of Medicine, Chicago, IL, United States., Menchaca MG; Section of Neonatology, Department of Pediatrics, UIHealth Children's Hospital of the University of Illinois at Chicago, Chicago, IL, United States., Siegel AP; Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States., Pillers DM; Section of Neonatology, Department of Pediatrics, UIHealth Children's Hospital of the University of Illinois at Chicago, Chicago, IL, United States., Gelovani JG; Provost Office, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, UAE.; Department of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI 48201, United States.; Dept. Radiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Avanaki K; Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States.; Section of Neonatology, Department of Pediatrics, UIHealth Children's Hospital of the University of Illinois at Chicago, Chicago, IL, United States.; Department of Dermatology, University of Illinois at Chicago, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Photoacoustics [Photoacoustics] 2023 Aug 24; Vol. 33, pp. 100549. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).
DOI:	10.1016/j.pacs.2023.100549
Abstrakt:	Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are common because the periventricular blood vessels are still developing up to 36 weeks and are fragile. Currently, transfontanelle ultrasound (US) imaging is utilized for screening for IVH and PVH, largely through the anterior fontanelle. However for mild hemorrhages, inconclusive diagnoses are common, leading to failure to detect IVH/PVH or, when other clinical symptoms are present, use of second stage neuroimaging modalities requiring transport of vulnerable patients. Yet even mild IVH/PVH increases the risk of moderate-severe neurodevelopmental impairment. Here, we demonstrate the capability of transfontanelle photoacoustic imaging (TFPAI) to detect IVH and PVH in-vivo in a large animal model. TFPAI was able to detect IVH/PVH as small as 0.3 mL in volume in the brain ( p  < 0.05). By contrast, US was able to detect hemorrhages as small as 0.5 mL. These preliminary results suggest TFPAI could be translated into a portable bedside imaging probe for improved diagnosis of clinically relevant brain hemorrhages in neonates. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier GmbH.)
Databáze:	MEDLINE
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