Risk and predictors of severity and mortality in patients with type 2 diabetes and COVID-19 in Dubai.

Autor:	Alawadi F; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Bashier A; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Bin Hussain AA; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Al-Hashmi N; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Bachet FAT; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Hassanein MMA; Department of Endocrinology, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Zidan MA; Department of Medical Education and Research, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Soued R; Department of Radiology, Mediclinic City Hospital, Dubai, United Arab Emirates., Khamis AH; College of Medicine, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Mukhopadhyay D; College of Medicine, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Abdul F; College of Medicine, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Osama A; College of Medicine, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Sulaiman F; College of Medicine, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates., Farooqi MH; Dubai Diabetes Center, Dubai Academic Health Corporation, Dubai, United Arab Emirates., Bayoumi RAL; Basic Medical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates. riad.bayoumi@mbru.ac.ae.
Jazyk:	angličtina
Zdroj:	World journal of diabetes [World J Diabetes] 2023 Aug 15; Vol. 14 (8), pp. 1259-1270.
DOI:	10.4239/wjd.v14.i8.1259
Abstrakt:	Background: Globally, patients with diabetes suffer from increased disease severity and mortality due to coronavirus disease 2019 (COVID-19). Old age, high body mass index (BMI), comorbidities, and complications of diabetes are recognized as major risk factors for infection severity and mortality. Aim: To investigate the risk and predictors of higher severity and mortality among in-hospital patients with COVID-19 and type 2 diabetes (T2D) during the first wave of the pandemic in Dubai (March-September 2020). Methods: In this cross-sectional nested case-control study, a total of 1083 patients with COVID-19 were recruited. This study included 890 men and 193 women. Of these, 427 had T2D and 656 were non-diabetic. The clinical, radiographic, and laboratory data of the patients with and without T2D were compared. Independent predictors of mortality in COVID-19 non-survivors were identified in patients with and without T2D. Results: T2D patients with COVID-19 were older and had higher BMI than those without T2D. They had higher rates of comorbidities such as hypertension, ischemic heart disease, heart failure, and more life-threatening complications. All laboratory parameters of disease severity were significantly higher than in those without T2D. Therefore, these patients had a longer hospital stay and a significantly higher mortality rate. They died from COVID-19 at a rate three times higher than patients without. Most laboratory and radiographic severity indices in non-survivors were high in patients with and without T2D. In the univariate analysis of the predictors of mortality among all COVID-19 non-survivors, significant associations were identified with old age, increased white blood cell count, lym-phopenia, and elevated serum troponin levels. In multivariate analysis, only lymphopenia was identified as an independent predictor of mortality among T2D non-survivors. Conclusion: Patients with COVID-19 and T2D were older with higher BMI, more comorbidities, higher disease severity indices, more severe proinflammatory state with cardiac involvement, and died from COVID-19 at three times the rate of patients without T2D. The identified mortality predictors will help healthcare workers prioritize the management of patients with COVID-19. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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