The Safety and Efficacy of Cryotherapy in the Prevention of Paclitaxel-Induced Neuropathy: A Systematic Review.
| Autor: | Hossain MF; Hospital Medicine, Ministry of Health, Upazila Health Complex, Kishoreganj, BGD., Kharel M; Medicine and Surgery, Jahurul Islam Medical College, Bhagalpur, BGD., Rajib MH; Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, BGD., Khan MA; Internal Medicine, Sylhet M.A.G (Muhammad Ataul Goni) Osmani Medical College, Sylhet, BGD., Anwar MY; Cardiology, 250 Bed District Sadar Hospital, Cox Bazar, BGD., Lamsal Y; Emergency Medicine, Sahara Hospital Pvt. Ltd., Pokhara, NPL., Aziz SN; Obstetrics and Gynaecology, University of Missouri, Columbia, USA.; Internal Medicine, Shaheed Suhrawardy Medical College, Dhaka, BGD. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Aug 24; Vol. 15 (8), pp. e44026. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.44026 |
| Abstrakt: | The chemotherapeutic agent paclitaxel has significantly enhanced the treatment of various types of cancer. However, the quality of life of cancer patients is often impacted by the painful and dose-restrictive paclitaxel side effect known as paclitaxel-induced peripheral neuropathy (PIPN). A non-pharmacological method called cryotherapy has shown promise in alleviating PIPN-related symptoms. In this systematic review, we aimed to evaluate the safety and effectiveness of cryotherapy in preventing PIPN. The review analyzed four randomized controlled trials (RCTs) involving individuals treated with paclitaxel for breast and gynecological cancer. Cryotherapy showed success in lowering PIPN symptoms in several studies, as judged by various outcome measures, although the findings varied. The safety profile of cryotherapy was typically good, with minimal side effects. However, methodological variations and small sample sizes in the studies analyzed limit drawing definitive conclusions from them. To obtain conclusive evidence, studies with standardized techniques and larger sample sizes are required. Further research is necessary to understand cryotherapy's potential mechanisms and long-term effects. This review highlights the potential of cryotherapy in the management of PIPN, explains how it works, and suggests future research topics to improve its application. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Hossain et al.) |
| Databáze: | MEDLINE |
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