Relationship between metalloproteinase-9 (MMP-9) expression and clinicopathology in colorectal cancer: a cross-sectional study.

Autor:	Mudatsir; Division of Digestive, Department of Surgery., Labeda I; Division of Digestive, Department of Surgery.; Division of Digestive, Department of Surgery, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia., Uwuratuw JA; Division of Digestive, Department of Surgery., Hendarto J; Departments of Public Health and Preventive Medicine., Warsinggih; Division of Digestive, Department of Surgery.; Division of Digestive, Department of Surgery, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia., Lusikooy RE; Division of Digestive, Department of Surgery.; Division of Digestive, Department of Surgery, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia., Mappincara; Division of Digestive, Department of Surgery., Sampetoding S; Division of Digestive, Department of Surgery.; Division of Digestive, Department of Surgery, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia., Kusuma MI; Division of Digestive, Department of Surgery.; Division of Digestive, Department of Surgery, Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia., Syarifuddin E; Division of Digestive, Department of Surgery., Arsyad A; Division of Digestive, Department of Surgery., Faruk M; Surgery, Faculty of Medicine.; Institute for Research and Community Services, Universitas Hasanuddin.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Jul 25; Vol. 85 (9), pp. 4277-4282. Date of Electronic Publication: 2023 Jul 25 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000000892
Abstrakt:	Introduction: According to the WHO's GLOBOCAN database, ~1,931,590 new colorectal cancer (CRC) cases and 915,607 CRC-related deaths occurred in 2020. The incidence of CRC in Indonesia is 8.6%, making it the fourth most common cancer. With CRC, matrix metalloproteinase-9 (MMP-9) has a role in tumour development and progression, such that patients with a higher MMP-9 expression had poorer survival. This study aimed to analyze the relationship between MMP-9 expression and clinicopathology in CRC patients. Methods: This was an analytic observational study with a cross-sectional research design. It was conducted from November 2021 to June 2022 with 52 patient tissue samples: these were subjected to MMP-9 immunohistochemistry stain, with the GeneTex (Irvine) MMP-9 monoclonal antibody. Patient data were collected with clinical variables based on medical records and histopathological examination by anatomy pathologists. Results: Primary tumour location, cancer staging, and histopathology grading were associated with MMP-9 ( P =0.016, P =0.001, P =0.049). The more proximal to the primary tumour, the higher the stage of cancer, and the higher the histopathological grade, thus the greater the expression of MMP-9. Conclusion: A significant relationship existed of primary tumour location, cancer staging, and histopathology grading with MMP-9 expression in CRC patients. MMP-9 expression could be a useful indicator for the clinical assessment of tumour biologic behaviour and prognosis in CRC patients. Competing Interests: The authors declare that they have no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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