Seroconversion of hepatitis B vaccine among patients from outpatient clinic in Georgia.

Autor:	Kanchelashvili G; Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.; The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Kamkamidze G; Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.; The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Davitadze M; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Bzishvili N; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Abzianidze T; Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Gulbiani L; Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.; The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia., Butsashvili M; Health Research Union, 8 Nutsubidze Street, 0177 Tbilisi, Georgia.; The University of Georgia, 77a Kostava Street, 0171 Tbilisi, Georgia.; Clinic 'NeoLab', 2b Topuria Street, 0159 Tbilisi, Georgia.
Jazyk:	angličtina
Zdroj:	Vaccine: X [Vaccine X] 2023 Aug 22; Vol. 15, pp. 100375. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023).
DOI:	10.1016/j.jvacx.2023.100375
Abstrakt:	Introduction: Hepatitis B virus (HBV) is a serious global health challenge with vaccination being the most effective preventive measure. However, several risk-factors may impact HBV vaccine immunogenicity. We aimed to evaluate the immunogenicity of the HBV vaccine. Methods: Participants' socio-demographic data were obtained from medical records. Anti-HBs testing was performed. Descriptive and bivariate analyses were performed. Results: Among 431 participants, 62.2 % (n = 268) were males. In all, 43.2 % (n = 186) had normal weight, 24.8 % (n = 107) were overweight, and 17.6 % (n = 76) had obesity. Seroconversion after 3-dose HBV vaccination was 74.7 %. Participants with normal weight had higher seroprevalence (n = 156/186, 83.9 %), compared with those with overweight (n = 72/107, 67.3 %) or obesity (n = 48/76, 63.2 %) (Normal weight vs overweight: aOR = 2.44, 95 % CI: 1.38-4.32 and normal weight vs obesity: aOR = 2.97, 95 % CI:1.61-5.47). Conclusion: BMI is an independent factor impairing the vaccine response. These findings urge for more tailored vaccination strategies with focus on higher risk populations. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).)
Databáze:	MEDLINE
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