Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection.

Autor:	Paskeviciute E; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Chen M; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University of Belfast, Belfast, Ireland., Xu H; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University of Belfast, Belfast, Ireland., Honoré B; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Vorum H; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.; Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark., Sørensen TL; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Christensen JP; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Thomsen AR; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Nissen MH; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Steffensen MA; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Aug 18; Vol. 14, pp. 1221511. Date of Electronic Publication: 2023 Aug 18 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1221511
Abstrakt:	During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more integrated in the systemic response to infection than was previously believed. In line with this, it was recently shown that a systemic acute virus infection leads to infiltration of CD8 T cells in the brains of immunocompetent mice. In this study, we extend these findings to the neurological tissue of the eye, namely the retina. We show that an acute systemic virus infection in mice leads to a transient CD8 T cell infiltration in the retina that is not directed by virus infection inside the retina. CD8 T cells were found throughout the retinal tissue, and had a high expression of CXCR6 and CXCR3, as also reported for tissue residing CD8 T cells in the lung and liver. We also show that the pigment epithelium lining the retina expresses CXCL16 (the ligand for CXCR6) similar to epithelial cells of the lung. Thus, our results suggest that the retina undergoes immune surveillance during a systemic infection, and that this surveillance appears to be directed by mechanisms similar to those described for non-privileged tissues. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Paskeviciute, Chen, Xu, Honoré, Vorum, Sørensen, Christensen, Thomsen, Nissen and Steffensen.)
Databáze:	MEDLINE
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